|Awarded On||November 18, 2020|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||The University of Texas Medical Branch at Galveston|
|Principal Investigator/Program Director||Guy Nir|
|Cancer Sites||Leukemia, Myeloma|
|Summary of Goals and Objectives||
The 3D organization of the genome is a regulator of gene expression. However, in different types of cancer, including multiple myeloma (MM) and chronic myelogenous leukemia (CML), the folding of chromosomes is altered, which impairs the proper regulation of transcriptional activity. In addition, genes located in such misfolded chromosomal loci are often involved in cancerous mechanisms. Despite the connection between genome organization and tumorigenesis, robust models of healthy and cancerous cells that rely on genome organization are lacking. This absence makes predicting which cells are likely to become cancerous due to impaired genomic organization impossible.
One reason for the inaccura...