|Awarded On||May 20, 2020|
|Title||Recruitment of First-Time, Tenure-Track Faculty Members|
|Award Mechanism||Recruitment of First-Time, Tenure-Track Faculty Members|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Matthew Parker|
|Cancer Sites||All Sites|
|Summary of Goals and Objectives||
Eukaryotic DNA replication is necessary for cell division. To initiate replication, three proteins, ORC, Cdc6 and Cdt1, co-assemble into a condensed liquid phase on chromosome surfaces to load the replicative helicase onto DNA. CDK•Cyc-dependent initiator phosphorylation regulates this process to ensure that it occurs once and only once per division cycle; mis-regulation leads to genomic instability, a hallmark of many cancers. Although aberrant CDK•Cyc activity is common in cancer, and regulation of replication initiation is necessary for genomic health, how these pathways conspire to drive genomic instability in cancer remain...