|Awarded On||February 15, 2023|
|Title||Elucidating the mutagenesis mechanism of BRAF in melanoma|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas at Austin|
|Principal Investigator/Program Director||Seongmin Lee|
The protein kinase BRAF activates MAP kinase signaling pathways that regulate cell proliferation. The oncogenic BRAF gene is mutated up to 70% of melanoma, the deadliest form of skin cancer. Interestingly, BRAF mutations predominantly occur at codon 600 (GTG) and are T-to-A transversions, leading to BRAF V600E mutations. While solar ultraviolet (UV) irradiation is the prime suspect for melanoma, the identity of DNA lesion responsible for the dominant BRAF mutations is unknown, limiting our understanding of melanoma-genesis mechanisms. This knowledge gap prompted us to search for DNA lesion driving the BRAF V600E mutagenesis. To gain mechanistic insights into the solar rays-induced BRAF muta...