|Awarded On||September 14, 2022|
|Title||Targeting Nitric Oxide Synthase (NOS) pathway to remodel obesity induced tumor inflammation in patients with TNBC|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The Methodist Hospital Research Institute|
|Principal Investigator/Program Director||Jenny Chang|
Obesity is a major health concern and contributes to various diseases including breast cancer. Triple-negative breast cancer (TNBC) is an aggressive and highly lethal subtype of breast cancer. Obese TNBC patients often have the worse outcome with a higher chance of resistance to traditional chemotherapy and increased risk of tumor recurrence. While the mechanism responsible for this outcome is unknown, evidence indicates its association with chronic inflammation. One of the inflammatory pathways being studied by our group is the nitric oxide synthases (NOS) pathway. We and others have shown that increased nitric oxide levels alter the tumor immune cell profile that lead to increased breast c...