|Awarded On||September 14, 2022|
|Title||A glia-to-neuron conversion for treating oral cancer pain|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas A&M University System Health Science Center|
|Principal Investigator/Program Director||Feng Tao|
|Cancer Sites||Head and Neck|
Head and neck cancer, including oral cancer, affects numerous patients worldwide and is directly associated with chronic pain, which markedly reduces quality of life in these patients. However, currently it remains unclear how such cancer pain is developed and how we can treat it successfully. In this project, we will address this problem and explore whether a cell conversion strategy can be used to develop a novel approach for treating chronic oral cancer pain. Our overall goal is to generate an unconventional perspective on chronic oral cancer pain treatment with a cell conversion approach, which is totally different from currently available pain therapies. If successful, the proposed stud...