|Awarded On||February 16, 2022|
|Title||Single-cell decoding of spatiotemporal and ecological evolution in early-stage KRAS- mutant lung cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Humam Kadara|
|Cancer Sites||Lung and Bronchus|
A large fraction of lung cancers contains genetic changes (called mutations) in a tumor promoting gene called KRAS. KRAS-mutant lung cancer, often very aggressive and notoriously difficult to treat, is the most common lung malignancy diagnosed in current or former smokers and the epidemic of this lethal disease will remain long after smoking incidence has dropped. It is widely appreciated that carcinogenic (such as smoking) exposure elicits tumor promoting molecular and inflammatory changes throughout the lung. Notably, the lung is ecologically rich with various cell populations besides the airway lining including diverse immune subsets that may participate in cancer. Yet, for a fatal malign...