|Awarded On||August 18, 2021|
|Title||Virulence Modulation of Helicobacter pylori, the Strongest Risk Factor for Gastric Cancer|
|Award Mechanism||High Impact/High Risk|
|Principal Investigator/Program Director||Christopher Kearney|
Helicobacter pylori is the strongest known risk factor for gastric cancer, which is the third leading cause of cancer-related deaths globally. H. pylori is one of the four main cancer-causing pathogens listed in the Texas Cancer Plan. It is not listed in Goal 5, which seeks to increase vaccination rates for the prevention of cancer because there is no available vaccine. Also it is resident in over 4.4 billion human beings and there is some evidence of beneficial health effects from this infection. And yet close to 700,000 deaths globally are attributable to gastric cancer every year. Even in the United States, 1 out of every 95 men will develop gastric cancer and the greatest H. pylori burd...