|Awarded On||August 19, 2020|
|Title||Targeting Plasma Membrane Spatial Dynamics to Suppress Obesity-Induced Colon Cancer|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas Agrilife Research|
|Principal Investigator/Program Director||Robert S Chapkin|
Less than 1.5% of total biomedical research funding is targeted to early detection and prevention of chronic disease. The increasing prevalence of adult and adolescent obesity and its associated risk of colon cancer reinforces the urgent need to elucidate the underlying mechanisms contributing to the promotion of colon cancer in obese individuals. An abundance of global epidemiological evidence suggests the risk of colon increases proportionally to body-mass index in men and women. In Texas, obesity is a major health concern as 70% of adults are considered overweight or obese. In preclinical studies, high-fat diet (HFD) induced-obesity has also been shown to accelerate gastrointestinal tumor...