Grant ID RP200467
Awarded On February 19, 2020
Title SREBP-2- Dependent Oncometabolites and Intestinal Tumorigenesis
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Luke J Engelking
Cancer Sites Small Intestine
Contracted Amount $900,000
Lay Summary

Obesity and high-fat diets are serious risk factors for intestinal cancers. The most rapidly-dividing cells in the human body reside in the intestine and rely on the proper functioning of actively dividing progenitor cells, such as intestinal stem cells (ISCs), to sustain it. Derangement of the signals that control the growth of ISCs causes cancer. Although fatty molecules, called lipids, are known to control the growth ISCs, the mechanisms by which specific lipids affect cancer development are not well understood. Lipid synthesis is controlled by a family of genes called sterol regulatory element-binding proteins (SREBPs). SREBP-2 makes cholesterol. My recent work has shown that SREBP-2 has...

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