Grant ID RP190599
Awarded On August 21, 2019
Title Epithelial memory of resolved inflammation as a driver of pancreatic cancer progression
Program Academic Research
Award Mechanism High Impact/High Risk
Institution/Organization The University of Texas M.D. Anderson Cancer Center
Principal Investigator/Program Director Andrea Viale
Cancer Sites Pancreas
Contracted Amount $199,804
Lay Summary

Inflammation is one of the major risk factors for pancreatic ductal adenocarcinoma, a tumor characterized by a very poor prognosis and projected to become the second leading cause of cancer death in United States in the next decade. As for other tumors, also in pancreatic cancer inflammation leads to accelerated tumor development promoting tumor growth through the activation of survival and proliferation programs in cancer cells. Recently, investigating the effects of inflammation on normal pancreatic epithelial cells we discovered that, even long after the complete resolution, transient inflammatory events prime epithelial cells to cooperate with mutated genes that drive tumors development....

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