|Awarded On||August 21, 2019|
|Title||Mechanism-based targeting of core module of the BAF complex in cancer|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Health Science Center at San Antonio|
|Principal Investigator/Program Director||Yogesh K Gupta|
In a human cell, the ATP-dependent large macromolecular assemblies such as BAF (BRG1/BRM-associated factors) complexes utilize energy from ATP hydrolysis to re-organize the three-dimensional architecture of chromatin and associated factors so that certain parts (called regulatory regions) of DNA are accessible to proteins known as transcription factors. These factors activate gene expression programs for normal and disease conditions. Normally, the expression levels and composition of BAF complexes, and transcription factors are tightly regulated to properly maintain the organization and integrity of the human genome. But in malignant cells (especially pediatric cancers), both assembly and r...