|Awarded On||February 21, 2019|
|Title||Characterization of CTCF-Mediated 3D Genome Organization and Transcriptional Regulation in Metastatic Prostate Cancer|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Ram S Mani|
Cancer progression and resistance to therapies are direct consequences of alterations in the three-dimensional (3D) organization of the genome. It is increasingly clear that although genes and their regulatory elements, termed enhancers, are located far apart in the DNA, they interact by a looping mechanism to promote gene expression by RNA Pol II. This looping interaction is cell type specific, and is mediated by proteins like CTCF. Cancer cells typically hijack these looping interactions to mis-pair gene enhancer looping, resulting in activation of oncogene expression by RNA Pol II. However, CTCF mediated gene-enhancer looping, resulting in activation of gene expression by RNA Pol II in a...