Grant ID RP190414
Awarded On August 21, 2019
Title Biochemical and Genetic Interrogation of EWSR1-FLI1 in Ewing Sarcoma
Program Academic Research
Award Mechanism Individual Investigator Research Awards for Cancer in Children and Adolescents
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director DavidG McFadden
Cancer Sites Bone, Sarcoma
Contracted Amount $926,257
Lay Summary

Cancers in children are frequently caused by the joining of two genes that are not normally together. These genes are called fusions genes. Ewing sarcoma and related tumors are one example of this type of cancer: Ewing sarcoma tumors nearly always appear to be cause by a family of fusion genes called EWSR1-FLI1 that controls whether other genes are turned on or off. By turning some genes on, and others off, EWSR1-FLI1 causes Ewing sarcoma. The EWSR1-FLI1 fusion gene represents a major challenge to discovering new treatments for Ewing sarcoma. There is not a straightforward way to generate drugs that block the action of EWSR1-FLI1. Therefore, understanding how EWSR1-FLI1 re-wires cel...

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