|Awarded On||February 21, 2019|
|Title||Noninvasive Detection and Assessment of Therapy Response in Multiple Myeloma Using Whole-Body MRI|
|Award Mechanism||Individual Investigator Research Awards for Clinical Translation|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Ananth J Madhuranthakam|
Multiple Myeloma (MM) is the second most common hematologic malignancy in the United States. MM originates in the bone marrow and eventually creates bone lesions, occurring in ~60% of patients at diagnosis, and in all patients over the course of the disease. It results in severe bone pain, hypercalcemia, and spinal cord compression leading to pathologic fractures or paralysis. Whole-body X-ray is currently used to identify bone lesions, however, they are most often detected only at advanced stages. The International Myeloma Working Group (IMWG) now recommends whole-body magnetic resonance imaging (WBMRI) as the preferred imaging technique for pretreatment assessment. However, MRI is most of...