|Awarded On||August 24, 2018|
|Title||Regulating Androgen Receptor as a Corepressor by Neurofibromin (NF1)|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Eric Chang|
To treat a given cancer patient with just the right medicine, we must thoroughly understand the molecular factors driving the disease. This project centers on the NF1 gene, the loss of which was first discovered to cause neurofibromatosis type-1, the world's most common hereditary genetic disorder affecting 1 in every 3,000 births. Patients with this disease often develop disfiguring neuronal tissue outgrowth, and have higher propensities for acquiring malignant diseases. We now know that NF1 can also be lost later in life in a wide range of common cancers, such as cancer of the breast, skin, central nervous system, ovaries, etc. Thus, NF1 is a critical tumor suppressor whose normal func...