|Awarded On||February 21, 2018|
|Title||Structural and Functional Characterization of the DNA Double Strand Break Processing Complex of Mre11-Rad50|
|Award Mechanism||Individual Investigator|
|Institution/Organization||Texas Tech University|
|Principal Investigator/Program Director||Michael Latham|
|Cancer Sites||Breast, Colorectal, Prostate|
A hallmark of various forms of cancer is genomic instability caused by DNA damage, which can arise from hereditary or sporadic mutations. To combat the daily onslaught of unwanted DNA modifications, several parallel DNA repair systems have evolved to sense and repair the various lesions that affect our genome. When one of these repair systems goes awry, carcinogenic mutations and rearrangement of the DNA can occur. However, the recent success of new chemotherapies has shown that knocking out a second repair pathway presents a viable option for the fight against cancer (i.e., PARP inhibitors). Thus, it is critical to understand DNA damage repair pathways for both cancer prevention and treatme...