|Awarded On||August 16, 2017|
|Title||Etiology and Prevention of Gastric Cancers by Mitigation of H pylori Mechanosensing|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas A&M Engineering Experiment Station|
|Principal Investigator/Program Director||Pushkar Lele|
Gastric cancer is the second-leading cause of cancer-related deaths in the world. It is estimated that around thousand Texans continue to die from this type of cancer each year, with unacceptably low 5-year survival rates. Helicobacter pylori, a gram-negative bacterium and a class 1 carcinogen, is the primary cause of gastric cancer especially in the lower part of the stomach. About 60% of the world population harbors these bacteria and people with long-term infection have a predisposition towards chronic atrophic gastritis, pre-cancerous modifications in the inner lining as well as certain types of lymphoma of the stomach. Significantly, once these bugs colonize the stomach the host immune ...