|Awarded On||May 18, 2016|
|Title||Amino Acid Sensing: Directing Cell Growth through mTORC1|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Jenna L Jewell|
|Cancer Sites||All Sites|
Growth is an essential process whereby cells and organisms accumulate mass and increase in size. Cells grow by responding to environmental cues that trigger signaling pathways to regulate growth. When these signaling pathways are constitutively turned on, the cell grows uncontrollably leading to cancer. One signaling pathway implicated in cancer is the mTORC1 pathway. In fact, mTORC1 is often referred to as the “master regulator” of cell growth. The mTORC1 pathway is constitutively active in many human cancers, and therapeutics like rapamycin that target and block the mTORC1 pathway, have shown promise in cancer patients in several clinical trials. Currently there are two rapamycin analogs, ...