|Awarded On||November 19, 2015|
|Title||Targeting Metastatic Pathways|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Lance S Terada|
|Cancer Sites||Lung and Bronchus|
Over 90% of cancer-related deaths are due to metastasis and are not from the primary tumor. Presently, however, no treatment options are specific for metastatic sites. In large part, this lack of therapeutic development has been due to the complex and multi-step nature of tumor cell metastasis, which requires multiple genes to be up- or down-regulated. The principal aim of this grant is to explore one particular approach to intervening in metastatic tumor behavior through targeting a “master controller” of such behavior. In recent years, DNA mutations have been found to work in concert with much more widespread changes in cancer cells’ chromatin (DNA+surrounding proteins). Such “epigene...