|Awarded On||May 20, 2015|
|Title||Dynamin GTPase: A novel pro-apoptotic cancer therapeutic target|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Sandra Schmid|
|Cancer Sites||All Sites|
Programmed cell death, or apoptosis, plays a critical role in the normal development and maintenance of tissues by eliminating infected, mutated or damaged cells in all multicellular organisms. Not surprisingly, deficiencies in the process of apoptosis are a hallmark of cancer. Apoptosis can be triggered by a class of molecules, called death receptors, that kill target cells upon activation by their corresponding ligands. Interestingly, one of these ligands, called TRAIL, selectively kills cancer cells and is being developed as a potential anti-cancer therapeutic. The large GTPase dynamin is best known for its role in clathrin-mediated endocytosis (CME), a major process regulating the select...