|Awarded On||February 18, 2015|
|Title||Role of TBK1 in Regulating Dendritic Cell Function and Antitumor Immunity.|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Shao-Cong Sun|
|Cancer Sites||All Sites|
Immunotherapy has become a highly promising approach for cancer treatment. The immune system is evolved as a mechanism that detects and attacks foreign substances, such as microbial pathogens. On the other hand, the immune system does not attack cells or tissues of our body, which is the so-called immune tolerance. Cancer cells accumulate genetic mutations, making them different from normal cells. However, because the differences between cancer cells and normal cells are very small, the immune system is usually tolerant to the cancer cells and does not mount strong responses to attack them. The general principle of tumor immunotherapy is to stimulate the tumor-specific T-cell responses stron...