Grant ID RP150232
Awarded On February 18, 2015
Title The Role of Progesterone Receptor in Early Stage Breast Cancer.
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization Baylor College of Medicine
Principal Investigator/Program Director Dean P Edwards
Cancer Sites Breast
Contracted Amount $864,661
Lay Summary

The estrogen receptor (ER) signaling axis stimulates growth and progression of human breast cancers and targeted anti-estrogen therapies are a standard of care treatment of ER+ tumors. However, it has become increasingly appreciated that the other ovarian steroid hormone progesterone (P4) also plays a role in breast tumorigenesis but progesterone receptor (PR) has not been fully exploited as a therapeutic target. During the reproductive years of women, P4 stimulates continuous cycles of proliferation of breast luminal epithelial cells. Clinical studies and other epidemiological studies indicate that P4 is a risk factor for breast cancer. A number of experimental mouse mammary tumor models ha...

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