|Awarded On||February 18, 2015|
|Title||Regulation of dormancy of metastatic prostate cancer cells by bone microenvironment|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas M.D. Anderson Cancer Center|
|Principal Investigator/Program Director||Sue-Hwa Lin|
|Cancer Sites||Bone, Prostate|
The majority of men who succumb to prostate cancer die of bone metastasis. Bone metastasis can occur years or decades after prostectomy, due to reactivation of disseminated tumor cells that had been dormant at the metastatic site in bone. The mechanisms that lead to tumor dormancy and reactivation are poorly understood. Identification of factors that cause tumor dormancy and the mechanisms by which tumors exit dormancy will lead to new strategies that prevent dormant disseminated tumor cells from reactivation in bone. Metastasis is attributed to properties of the tumor cells (seed) and their interaction with the microenvironment of the metastasized organs (soil). It is possible that microen...