Grant ID RP150166
Awarded On February 18, 2015
Title Prostate Cancer Chemoprevention with Resveratrol
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Health Science Center at San Antonio
Principal Investigator/Program Director Addanki Kumar
Cancer Sites Prostate
Contracted Amount $900,000
Lay Summary

In this proposal we are testing the ability of Resveratrol (RES) present in grapes, nuts and berries to prevent the progression of high-grade PIN (HGPIN) to clinical prostate cancer. Men who have HGPIN lesions in their prostate are at a high risk of developing clinical prostate cancer. This process takes many years therefore it is feasible to target disease progression with chemopreventive agents. Our laboratory has a rich history of testing naturally occurring chemicals from botanicals as chemopreventive agents. Published population-based case control studies showed a statistically significant decrease in relative prostate cancer risk in men consuming red wine, which also contains RES. Howe...

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