Grant ID RP150053
Awarded On February 18, 2015
Title Mechanisms of nuclear import and export in cancer
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Yuh Min Chook
Cancer Sites All Sites
Contracted Amount $745,064
Lay Summary

CRM1 transports protein cargos out of the cell nucleus. In cancer, many tumor suppressor cargos are inappropriately transported by CRM1, thus preventing cancer cell death and causing resistance to therapy. Anti-CRM1 drug Selinexor reverts cargo misplacement and causes cancer cell death. The drug is in 12 Phase 1 and 2 clinical trials targeting many cancers. Selinexor is well tolerated, unlike an older CRM1 blocker named Leptomycin B (LMB), which was toxic in patients. Aim 1 of this proposal focuses on understanding how the two drugs act differently in cells. We will discover how Selinexor targets CRM1 to be destroyed or degraded and why this effect is absent with LMB. We will learn if this f...

Read More