Grant ID RP140661
Awarded On August 20, 2014
Title Analyses of the Regulatory Mechanisms of Tankyrase and Its Role in Tumorigenesis
Program Academic Research
Award Mechanism Individual Investigator
Institution/Organization The University of Texas Southwestern Medical Center
Principal Investigator/Program Director Xuewu Zhang
Cancer Sites Colorectal, Lung and Bronchus, Prostate
Contracted Amount $876,751
Lay Summary

Tankyrases are members of a group of enzymes called PARPs, which modify their target proteins by adding one or a polymer chain of the ADP-ribose group. This modification regulates various aspects of many proteins, including their biological activity and destruction. Through this modification, tankyrase controls several important cellular processes such as cell proliferation and telomere homeostasis. Dysregulation of these processes is often associated with cancer. Therefore, inhibition of tankyrases by small molecule inhibitors is a promising strategy for targeted cancer therapy. However, side effects of current inhibitors of tankyrases, due mainly to off-target inhibition of other PARP fami...

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