|Awarded On||August 20, 2014|
|Title||Screening for Melanoma Genes Using Natural Hybrid Incompatibilities|
|Award Mechanism||High Impact/High Risk|
|Institution/Organization||Texas A&M University|
|Principal Investigator/Program Director||Gil Rosenthal|
Identifying the genes responsible for particular cancers is critical for prevention, diagnosis, and treatment. Looking for genes associated with cancer risk in humans is complicated both by environmental factors and by the fact that cancer often depends not on a single genetic mutation, but on an abnormal interaction between multiple genes. The proposed study takes advantage of natural variation and natural selection in wild populations of swordtail fish. Some swordtail species develop spontaneous melanomas – skin cancers – while others don’t. Using state-of-the-art genomic techniques, this study will use natural hybrids between a melanoma-producing species and one that doesn’t, to pinpoint...