|Awarded On||August 20, 2014|
|Title||Noninvasive Identification of Prostate Tumor Hypoxia as a Prognostic Biomarker of Radiation Response|
|Award Mechanism||Individual Investigator|
|Institution/Organization||The University of Texas Southwestern Medical Center|
|Principal Investigator/Program Director||Ralph P Mason|
There is increasing evidence that hypoxia (lack of oxygen) is associated with more aggressive prostate cancer. Several studies have reported resistance to radiation therapy, increased likelihood of biochemical failure and metastatic spread. Those studies required needle electrodes or biopsy specimens, both approaches being highly invasive and providing representative samples only, which may miss crucial tumor components. At this time there is no convenient method to measure prostate cancer hypoxia non-invasively. We will develop and validate a new imaging biomarker to assess prostate tumor hypoxia and demonstrate its relevance to tumor control and resistance to therapy. Magnetic resonance im...