| Grant ID | RP120588 |
| Awarded On | November 02, 2011 |
| Title | Targeting the Acidic Tumor Microenvironment with Renal Clearable and pH Responsive Luminescent Gold Nanoparticles |
| Program | Academic Research |
| Award Mechanism | Individual Investigator |
| Institution/Organization | The University of Texas at Dallas |
| Principal Investigator/Program Director | Jie Zheng |
| Cancer Sites | All Sites |
| Contracted Amount | $1,259,790 |
| Lay Summary |
Multifunctional nanoparticles allow the combination of a variety of molecular imaging modalities and local treatment of lesions, potentially catalyzing the shift of our current medical paradigm to “earlier detection and prevention”. In particular, AuNPs with broad material properties hold great promise in cancer detection and therapy. However, several challenges remain to be addressed before they can be used as anticancer nanomedicines: (1) suboptimal in vivo pharmacokinetics as represented by high accumulation in the reticuloendothelial system (RES) organs (e.g. liver, spleen, bone marrow) and short blood circulation time; (2) severe nonspecific serum protein adsorption; (3) lack of in vivo... |