Zhigao Wang, PhD

  • Recruited to: The University of Texas Southwestern Medical Center
  • Award: First-Time, Tenure-Track Faculty Member

Dr. Wang received his PhD in 2004 in Dr. Eric Olson's lab at UT Southwestern Medical Center, then joined the lab of Dr. Xiaodong Wang for his post-doctoral training. In 2012, he became an assistant professor in the Department of Molecular Biology.

Dr. Wang’s research has provided new insights into necrotic cell death pathways and identified many chemical inhibitors of necrosis, which potentially will lead to therapeutic strategies to treat necrosis-associated diseases. Activation of the necrotic pathways in tumors that are highly resistant to apoptosis will be a novel direction in cancer treatment.

At UT Southwestern, Dr. Wang continues investigating the mechanisms of necrotic cell death, especially the executioners of the process, using unique chemical and biological tools. The in vivo functions of the key components of the necrosis pathways will also be investigated using mouse genetics and chemical biology. The ultimate goal of his research is to apply the knowledge to develop novel pharmacological interventions to treat necrosis-associated human diseases.